TILT is building a pipeline of innovative cancer immunotherapies targeted at treating solid tumors.
The power of TILT’s approach which enables its proprietary oncolytic viruses to be encoded with a variety of cytokines, means that it should have applicability across a wide range of cancer indications, including melanoma, head and neck cancer, and cancers of the ovary, lungs and pancreas.
- Product/Program: TILT-123; TILT-T215
- Indication: Melanoma (EU)
- Description: Monotherapy safety for TILT-123 and use with TILs
- Development Status: Phase 1 trials in Europe; Herlev Denmark, Nantes France. Patient recruitment is open in Denmark. Site in France is pending approval.
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TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.
- Product/Program: TILT-123; TILT-T115
- Indication: Solid Tumors (EU)
- Description: Phase 1 monotherapy safety for TILT-123
- Development status: Phase 1 trials in Europe; Helsinki University Hospital, Finland and Docrates Hospital, Finland
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TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2
- Product/Program: TILT-123 TILT-T215arm2
- Indication: Solid Tumors (EU)
- Description: Collaboration with Merck / Pfizer for the use of avelumab (anti-PD-L1)
- Development status: IND stage; target date for initiating clinical studies H1 2021
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TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.
- Product/Program: TILT-123; TILT-T563
- Indication: Ovarian cancer (US)
- Description: Collaboration with anti-PD-1 company (undisclosed)
- Development status: Pending Phase 1 trials at the Mayo clinic with Principal Investigator Mathew Block, M.D., Ph.D. Aim to file an IND in Q1 2021
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TILT-123 is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.
- Product/Program: TILT-123; TILT-T392
- Indication: Solid tumors (US)
- Description: Collaboration with University of Pennsylvania for the use of CAR T therapy. Available for partnering.
- Development status: CMC/IND stage
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TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.
- Product: TILT-123
- Indication: Biotheus indications (CN)
- Description: License agreement with Biotheus
- Development status: Poised for Phase 1
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TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.
- Product: TILT-234
- Indication: Solid tumors (US)
- Description: Ready to enter CMC and regulatory studies. For systemic and intravenous use to enable Dendritic cell therapy. Available for out-licensing
- Development status: CMC/IND stage
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TILT-234 structure: Based on Adenovirus serotype 3 (Ad3) genome that is armed with human CD40L.
- Product: TILT-452
- Indication: Solid Tumors
- Description: Local delivery of next generation payloads.
- Development status: Preclinical
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TILT-452 structure: Ad5/3 with double selectivity for safety and for both systemic and intravenous use. Arming is specific for T-cell targeting.
- Product: TILT-321
- Indication: Solid Tumors
- Description: T-cell recruitment into tumors and local activation. Local delivery of bispecific antibody
- Development status: Discovery
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TILT-321 structure: Ad5/3 coding for a bispecific antibody
Science
Our patented TILT® technology, based on oncolytic viral therapies, modifies the tumour microenvironment and eliminates its ability to suppress immune responses to cancer, thereby enhancing T-cell therapies such as checkpoint inhibitors and CAR T therapies.
Partners
Our pioneering approach has been recognized by industry leaders including Germany’s Merck KGaA and the USA’s Pfizer and Biotheus, a privately held Chinese biotechnology company.