Pipeline

TILT is building a pipeline of innovative cancer immunotherapies targeted at treating solid tumors.

The power of TILT’s approach which enables its proprietary oncolytic viruses to be encoded with a variety of cytokines, means that it should have applicability across a wide range of cancer indications, including melanoma, head and neck cancer, and cancers of the ovary, lungs and pancreas.

Discovery
Pre-clinical
IND
Phase I
  • Product/Program: TILT-123; TILT-T215
  • Indication: Melanoma (EU)
  • Description: Monotherapy safety for TILT-123 and use with TILs
  • Development Status: Phase 1 trials in Europe; Herlev Denmark, Nantes France. Patient recruitment is open in Denmark. Site in France is pending approval.
  • TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.

Discovery
Pre-clinical
IND
Phase I
  • Product/Program: TILT-123; TILT-T115
  • Indication: Solid Tumors (EU)
  • Description: Phase 1 monotherapy safety for TILT-123
  • Development status: Phase 1 trials in Europe; Helsinki University Hospital, Finland and Docrates Hospital, Finland
  • TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2

Discovery
Pre-clinical
IND
Phase I
  • Product/Program: TILT-123 TILT-T215arm2
  • Indication: Solid Tumors (EU)
  • Description: Collaboration with Merck / Pfizer for the use of avelumab (anti-PD-L1)
  • Development status: IND stage; target date for initiating clinical studies H1 2021
  • TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.

Discovery
Pre-clinical
IND
Phase I
  • Product/Program: TILT-123; TILT-T563
  • Indication: Ovarian cancer (US)
  • Description: Collaboration with anti-PD-1 company (undisclosed)
  • Development status: Pending Phase 1 trials at the Mayo clinic with Principal Investigator Mathew Block, M.D., Ph.D. Aim to file an IND in Q1 2021
  • TILT-123 is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.

Discovery
Pre-clinical
IND
Phase I
  • Product/Program: TILT-123; TILT-T392
  • Indication: Solid tumors (US)
  • Description: Collaboration with University of Pennsylvania for the use of CAR T therapy. Available for partnering.
  • Development status: CMC/IND stage
  • TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.

     

Discovery
Pre-clinical
IND
Phase I
  • Product: TILT-123
  • Indication: Biotheus indications (CN)
  • Description: License agreement with Biotheus
  • Development status: Poised for Phase 1
  • TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2.

Discovery
Pre-clinical
IND
Phase I
  • Product: TILT-234
  • Indication: Solid tumors (US)
  • Description: Ready to enter CMC and regulatory studies. For systemic and intravenous use to enable Dendritic cell therapy. Available for out-licensing
  • Development status: CMC/IND stage
  • TILT-234 structure: Based on Adenovirus serotype 3 (Ad3) genome that is armed with human CD40L.

Discovery
Pre-clinical
IND
Phase I
  • Product: TILT-452
  • Indication: Solid Tumors
  • Description: Local delivery of next generation payloads.
  • Development status: Preclinical
  • TILT-452 structure: Ad5/3 with double selectivity for safety and for both systemic and intravenous use. Arming is specific for T-cell targeting.

Discovery
Pre-clinical
IND
Phase I
  • Product: TILT-321
  • Indication: Solid Tumors
  • Description: T-cell recruitment into tumors and local activation. Local delivery of bispecific antibody
  • Development status: Discovery
  • TILT-321 structure: Ad5/3 coding for a bispecific antibody

Science

Our patented TILT® technology, based on oncolytic viral therapies, modifies the tumour microenvironment and eliminates its ability to suppress immune responses to cancer, thereby enhancing T-cell therapies such as checkpoint inhibitors and CAR T therapies.

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Partners

Our pioneering approach has been recognized by industry leaders including Germany’s Merck KGaA and the USA’s Pfizer and Biotheus, a privately held Chinese biotechnology company.

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