TILT Biotherapeutics is a clinical-stage biotechnology company developing cancer immunotherapies based on its proprietary, best-in-class oncolytic adenoviruses armed with molecules including cytokines that can stimulate, or enhance T-cell responses.
The Company’s patented technology is about oncolytic immunotherapies that modify the tumor microenvironment and eliminates its ability to suppress immune responses to cancer. This therapeutic approach supports the enhancement of combination T cell therapies such as checkpoint inhibitors and CAR T therapies. The technology has the advantage that it can be delivered locally and systemically.
TILT’s lead asset, TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2. TILT-123 has demonstrated a 100% response rate in preclinical cancer models in vivo, and it is currently in Phase 1 clinical trials in combination with tumor infiltrating lymphocytes (TIL) therapy in Europe.
Partnered clinical programs
The Company’s pioneering approach has been recognized by industry leaders including Germany’s Merck KGaA and the USA’s Pfizer, who are collaborating to investigate TILT-123’s therapeutic effect in combination with the PD-L1 checkpoint inhibitor, Avelumab (Bavencio®), in clinical trials.
In 2019, TILT established an additional partnership with Biotheus, a privately held Chinese company based in Zhuhai, Guangdong, China, for the development and commercialization of TILT’s proprietary oncolytic virus TILT-123 in Greater China.
History and investors
Based in Helsinki, Finland, the Company was established in 2013 as a spin-out from the University of Helsinki, with early stage funding from Lifeline Ventures, angel investors, Business Finland, and the European Innovation Council (EIC).