About TILT

TILT Biotherapeutics is a clinical-stage biotechnology company developing cancer immunotherapies based on its proprietary, best-in-class oncolytic adenoviruses armed with molecules including cytokines that can stimulate, or enhance T-cell responses.


The Company’s patented technology is about oncolytic immunotherapies that modify the tumor microenvironment and eliminates its ability to suppress immune responses to cancer. This therapeutic approach supports the enhancement of combination T cell therapies such as checkpoint inhibitors and CAR T and TIL therapies. The technology has the advantage that it can be delivered locally and systemically.

Clinical pipeline

TILT’s lead asset, TILT-123, is a 5/3 chimeric serotype adenovirus armed with two human T- cell stimulating cytokines; TNF alpha and IL-2. TILT-123 has demonstrated a 100% response rate in preclinical cancer models in vivo, and it is currently under study in multiple Phase 1 clinical trials, in monotherapy and in combination with different immunotherapies in Europe and USA.

Partnered clinical programs

The Company’s pioneering approach has been recognized by industry leaders. It has two collaborations with MSD, a tradename of Merck & Co., Inc., investigating TILT-123 in combination with KEYTRUDA® (pembrolizumab) in ovarian cancer (NCT05271318) and in refractory non-small cell lung cancer (NCT06125197). The Company is also collaborating with Merck KGaA, Darmstadt, Germany, and investigating TILT-123 in combination with avelumab.

History and investors

Based in Helsinki, Finland and Boston, USA, the Company was established in 2013 as a spin-out from University of Helsinki, leveraging on patient observations and proof of concept data gained by our scientific founders from 290 patients treated with 10 different types of oncolytic viruses. The company has received funding from Lifeline Ventures, angel investors, Business Finland, the European Innovation Council (EIC), and the US Department of Defence.